Decoding the Oncogenic Signals from the Long Non-Coding RNAs

Cancer is one of the leading causes death worldwide. Multifactorial etiology cancer and tumor heterogeneity are two most acute challenges in existing diagnostic therapeutic strategies for cancer. An effective precision medicine strategy to overcome these requires a clear understanding transcriptomic landscape cells. Recent innovative breakthroughs high-throughput sequencing technologies have identified oncogenic or tumor-suppressor role several long non-coding RNAs (lncRNAs). LncRNAs been characterized as regulating various signaling cascades which involved pathobiology They modulate cell survival, proliferation, metabolism, invasive metastasis, stemness, therapy-resistance through their interactions with specific sets proteins, miRNAs other RNAs, mRNAs, DNAs By virtue ability regulate multiple genes cognate pathways, lncRNAs emerging potential candidates diagnostic, prognostic, targets. This review focused on providing insight into mechanisms by different play critical growth, diagnosis, prognosis, therapy.